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GVKBIO conducts efficacy studies in the therapeutic areas of inflammation, pain and metabolic diseases using animal models. We use a wide range of technologies such as immunoassay, fluorescence, chemiluminescence, LC-MS/MS to measure biological process/ or analyte, to understand mechanisms or validate preclinical biomarkers.

Inflammation
  • Carrageenan induced inflammation
  • Ear swelling test in mice
  • Arthritis Model
    • Adjuvant induced
    • Collagen induced
  • Septic Shock -LPS induced
  • Inflammatory Bowel disease model

Pain
  • Inflammation pain (Hyperalgesia): Carrageenan or CFA induced
  • Nociception: Hot Plate and Tail flick
  • Writhing: Acetic acid induced /PQ writhing
  • Neuropathic pain: Taxol Induced Neuropathic Pain/ CFA Induced RA and RA Pain

Metabolic Disorders
  • STZ/Alloxan induced diabetic model
  • OGTT/IVGTT in mice and rats
  • Fructose induced lipidaemia model
  • Diet induced diabetic model
  • Type II diabetes model
  • Triton induced lipidaemia model
  • Cholesterol fed Model

Others

  • Depression: Forced Swimming Test
  • Anxiety: Marble Burying
  • Multiple sclerosis: Experimental Autoimmune Encephalomyelitis (EAE) and Delayed-Type
    Hypersensitivity (DTH) in rats
  • Epilepsy: Pentylenetetrazole induced convulsions in mice
 
   
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