GVKBIO conducts efficacy studies in the therapeutic areas of inflammation, pain and metabolic diseases using animal models. We use a wide range of technologies such as immunoassay, fluorescence, chemiluminescence, LC-MS/MS to measure biological process/ or analyte, to understand mechanisms or validate preclinical biomarkers.
Inflammation
Carrageenan induced inflammation
Ear swelling test in mice
Arthritis Model
Adjuvant induced
Collagen induced
Septic Shock -LPS induced
Inflammatory Bowel disease model
Pain
Inflammation pain (Hyperalgesia): Carrageenan or CFA induced
Nociception: Hot Plate and Tail flick
Writhing: Acetic acid induced /PQ writhing
Neuropathic pain: Taxol Induced Neuropathic Pain/ CFA Induced RA and RA Pain
Metabolic Disorders
STZ/Alloxan induced diabetic model
OGTT/IVGTT in mice and rats
Fructose induced lipidaemia model
Diet induced diabetic model
Type II diabetes model
Triton induced lipidaemia model
Cholesterol fed Model
Others
Depression: Forced Swimming Test
Anxiety: Marble Burying
Multiple sclerosis: Experimental Autoimmune Encephalomyelitis (EAE) and Delayed-Type
Hypersensitivity (DTH) in rats
Epilepsy: Pentylenetetrazole induced convulsions in mice
