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GVKBIO conducts efficacy studies in the therapeutic areas of inflammation, pain and metabolic diseases using animal models. We use a wide range of technologies such as immunoassay, fluorescence, chemiluminescence, LC-MS/MS to measure biological process/ or analyte, to understand mechanisms or validate preclinical biomarkers.
Inflammation
- Carrageenan induced inflammation
- Ear swelling test in mice
- Arthritis Model
- Adjuvant induced
- Collagen induced
- Septic Shock -LPS induced
- Inflammatory Bowel disease model
Pain
- Inflammation pain (Hyperalgesia): Carrageenan or CFA induced
- Nociception: Hot Plate and Tail flick
- Writhing: Acetic acid induced /PQ writhing
- Neuropathic pain: Taxol Induced Neuropathic Pain/ CFA Induced RA and RA Pain
Metabolic Disorders
- STZ/Alloxan induced diabetic model
- OGTT/IVGTT in mice and rats
- Fructose induced lipidaemia model
- Diet induced diabetic model
- Type II diabetes model
- Triton induced lipidaemia model
- Cholesterol fed Model
Others
- Depression: Forced Swimming Test
- Anxiety: Marble Burying
- Multiple sclerosis: Experimental Autoimmune Encephalomyelitis (EAE) and Delayed-Type
Hypersensitivity (DTH) in rats
- Epilepsy: Pentylenetetrazole induced convulsions in mice
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