Biology Services

Biological assessment of New Molecular Entities (NMEs) plays a crucial role in ascertaining structure activity relationships, potency, selectivity, druggability and in vivo efficacy evaluation. The research scientists in the Biology Department at GVK BIO work closely in an integrated manner with a significantly larger talent pool of more than 1000 scientists in Medicinal & Synthetic Chemistry, Integrated Drug Discovery, Bioinformatics, Cheminformatics & Data Analytics.

Within the Biology department, our capabilities include reagent generation, high-throughput screening, assay development, biomarker validation, radiometric assays, DMPK, animal pharmacology (disease models) and exploratory toxicology for small molecules and biologics.

In addition to the standalone services, one of the principal benefits to our clients is our Integrated Services Platform to influence and guide a drug discovery program from inception to IND filing. With GVK BIO, clients have access to multiple and seamless outsourcing choices across the drug discovery chain, ensuring speedy implementation of their research projects.

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Team

The team of Biologists at GVK BIO include some of the best professionals in the industry with experience in both domestic and global pharmaceutical companies. Each one of them contribute their special skills in his/her area of expertise. A passionate team with a wide spectrum of expertise allows the unit to tackle any problem in the area of drug discovery.

Our scientists offer a comprehensive range of proficiency assuring quality services to support a wide range of applications and research for today’s quest in discovery science. The team has a profound size of Ph.D.s and a skilled multidisciplinary team with experience ranging from 3 to 14 years in relevant areas.

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Infrastructure

To facilitate quality research and ensure timely delivery, the Biology facility at GVK BIO is equipped with state-of-the-art instrumentation, modern infrastructure and cutting edge processes. The infrastructure comprises various laboratories ,such as, the wet experimental area, approved hot labs for working with Radioactive Isotopes, laboratories with analytical instruments and a fully equipped Cell Culture lab.

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Radioactive Lab

State-of-the-art AERB India accredited ‘Type III lab’

Permission to handle 14C, 3H, 32P, 33P, 35S, 125I, 51Cr

Semi-automated assay platform – Microbeta Top Count (384 & 96 well) with 12 detectors

Assay Development & Screening Lab

Spectramax Plus 384 spectrophotometer by Molecular Devices and Fluorescence reader

Radioactivity Count by Top Count (Perkin Elmer)

Biomek Fx & Nx, Tomtec Liquid Handling and Sample preparation system

Watson LIMS and WinNonlin

Quant studio 6-flux qPCR

Nano drop

Mini-G

Fujifilm LAS400 imaging system

AKTA Explorer

Wave bioreactor

Biomek NX / FX

Cytomat

Multidrop Combi dispenser

Envision

BMG Polarstar

FACS Verse

FLIPR Tetra

EVOS Fluorescent Microscope

Spectramax

RapidStak

Topcount NXT

Microbeta2

Phosphoimager

HPLC with Radioactive detector

Flexdrop III EX

Elx 405 Select CW

Animal Pharmacology

AAALAC accredited facility

In-house facility for rodent equipped IVC cages and study for in-life PK and animal model

Registered with CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals), Government of India

Spontaneous Locomotor Anaesthesiometer, Tail Suspension Test, Plantar, Plantar Von Frey, Hot Plate, Tail Flick, Transonic ECG, BP & Blood Flow Meter with Emka Software

Gas Anaesthesiometer, Vernier Calipers, Water Plethysmometer, Glucometer, Graphpad software for statistical analysis

Molecular Biology Lab

Fully equipped lab to perform cloning, bacterial culture, protein expression and purification

Gel imaging system, wave bioreactor

ABS Gradient PCR, AKTA FPLC System, etc.

High speed centrifuge, freeze dryer (Lyophiliser)

Freezers (-80˚C and -20˚C)

Cell Culture Lab

Equipped to support radioactive and fluorescent based enzyme assays

Envision, BMG Polastar, Spectramax UV/VIS spectrophotometer, Fluorescence Imaging

Biomek Fx & Nx, Tomtec Liquid Handling and Sample Preparation System

Well-established P2 cell culture lab equipped with Laminar flow hoods, CO2 incubators, wave bioreactor, multidrop dispenser, etc.

Repository of cell lines maintained (transformed and recombinant)

DMPK & Bioanalytical Lab

Bioanalysis: LC-MS/MS

SCIEX-4000 with HTS-PAL Autosampler and Agilent 1200 HPLC

SCIEX-3200 Q trap with Agilent 1200 HPLC with PDA detector

SCIEX-3000 with Shimadzu Prominence with UV detector

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