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商品・サービス / 設備

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設備

Lab scale

  • Over 9200 sq. ft. Lab area & 80 Fume hoods
  • Buchi / Heidolph Rotovaps  (1 L to 20 L)
  • PAR Hydrogenators (250 mL to 2 L)
  • Autoclave (600 mL to 10 L)
  • Vacuum oven, Hot air oven & Deep freezer storage
  • Double jacketed reactor – Lara Reactor-Ready ®
    • Reactors from 250ml to 2 liters
    • Temperature range of -70°C to +200°C
    • Multiple Agitators for each requirements
    • pH Probes
    • Three Single Fluid Heating & Cooling Systems  (Huber)

Kilo Scale Manufacturing

  • Kilo Lab 1
    • SS and Glass lined reactors
    • Capacities ranging from 20 – 250 L
    • Individual reactor suites
    • Wide range of reaction temperatures (-70°C to 200°C)
    • Necessary support equipment for filtration, drying, milling, sieving, etc.
    • Total Kilo Lab reaction volume ~1200 L
  • Pilot Plant
    • SS, Glass & Glass lined reactors
    • Capacities ranging from 50 – 2000 L
    • Total Pilot Plant reaction volume ~ 8200 L
  •  Hydrogenation & Block E
    • Operating pressure – 20 Bar
    • Hydrogenation capacities ranging from 100 – 1000 L
    • SS and Glass Lined reactors
    • Total hydrogenation reaction volume ~ 1100 L
    • Total Block E reaction volume  ~ 19100 L

Large Scale Manufacturing Infrastructure

  • Manufacturing Block A
    • Manufacturing of APIs and Intermediates
    • SS & Glass lined reactors
    • Capacities ranging from 500 – 6000 L
    • Reaction temperatures ranging from -70°C to 240°C
    • Powder processing area
    • Class 100,000 clean room facility
  • Manufacturing Block B
    • Manufacturing of APIs and Intermediates
    • SS, Glass & Glass lined reactors
    • Separation equipment
    • Capacities ranging from 1600 – 4000 L
    • Class 100,000 Powder processing area
    • Sifters, Dryers, Millers, Sieving machines, Micronizers & Blenders
    • Manufacturing blocks combined reaction volume ~ 70000 L
    • Total  reaction volume ~ 99,000 L

cGMP compliant Custom Manufacturing – Block F

  • Two Independent Kilo Labs & One Pilot Plant module
    • Kilo Labs – 8 reactors. Reactor capacity ranging from 50 L to 200 L
    • Pilot Plant – 15 reactors. Reactor capacity ranging from 250 L to 3000 L
    • Reactor MOC includes – Hastelloy reactor, AGR, GL reactors and SS-316
  • Independent and dedicated powder processing area with separate AHU– Class 100,000
  • Necessary support equipment:
    • Centrifuges (SS/Halar Lined)
    • Dryers
    • Filters
    • Sifters
    • Blenders
    • Micronizer
  • Utilities: Hot Oil (250°C) and  Huber system (-85 to +200°C )
  • Vacuum system (0.1 Torr) and Purified Water – USP 30

Analytical Infrastructure

  • UPLC (1) & RRLC(3) with PDA
  • HPLC  (10) with PDA/UV , ELSD & RI detectors
  • Preparative HPLC with auto purification
  • SFC : Normal & Prep
  • GC with Head Space (4)
  • UV, FT-IR and Polarimeter
  • LC-MS/MS – Waters Q Premier coupled with UPLC
  • GC- MS
  • NMR (400 & 300 MHz)
  • GC- MS
  • DSC  
  • Fluorescence reader for protein analysis and *PXRD, Single Crystal XRD , TGA, DVS, SAA
  • SEM, ICP- MS, ICP- OES, AAS