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Metabolism

  • Half-life/clearance determination using Microsomes/Hepatocytes/S9 fractions/CYP across species (Human/Rat/Mouse/Dog/Monkey)
  • CYP inhibition (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and 2C8)
  • Drug – drug interaction studies
  • Pathway determination (Phase I and Phase II)
  • Metabolite identification with Microsomes/Hepatocytes and S9 fraction across species (Human/Rat/Mouse/Dog/Monkey) using Light Sight Met ID
  • Identification of reactive metabolites