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Products & Services / High Throughput Screening

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High Throughput Screening

GVK BIO offers High Throughput Screening (HTS) for biochemical and cell-based assays, against numerous target classes such as GPCR, Ion Channel, Transporters and Enzymes. We can execute HTS on assay panels developed in-house, supplied by clients or de-novo assays for a novel target.

The HTS facility at GVK BIO can process more than 30,000 data points in a single day and is suited for both mammalian cell-based and biochemical assays in 96 and 384 well formats. These campaigns help identify several hit molecules. We screen client-provided compounds or vendor libraries, by facilitating access to vendor libraries.

Infrastructure

  • Liquid handlers (Biomek FX with 384 well and 96 well head)
  • Biomek NX with 8 channel head for compound dilution and cherry picking
  • Cytomat integrated with liquid handler that can process up to 170 plates at a time
  • Integrated temperature controlled workstations (-40oC to 200oC) in liquid handlers
  • Multimode readers (BMG Polarstar, ENVISION, Spectramax, etc.)
  • Scintillation counters (Topcount, Micro Beta)
  • Rapid stacks for flexible integrations
  • Reagent dispensers (Multidrop Combi, Flexdrop, Microfill)
  • FLIPR
  • AKTA Explorer   
  • Molecular Biology labs
  • Microbiology labs
  • Insect and mammalian cell culture facilities
  • Scale-up up to 20 liters using wave bioreactor