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In vivo PK Service

Early profiling of pharmacokinetic parameters of a compound assists comprehension of liabilities and success of the program at subsequent stages. The GVK BIO vivarium is AAALAC certified and registered with CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals), Government of India. In our rodent facilities, animals are housed in Individual Ventilated Cages (IVC) in controlled temperature (22oC to 25oC) and relative humidity (30%-70%) maintained at 12h/12h light/dark cycle.

We perform pharmacokinetic studies in species like Rat, Mouse, Hamster, Dog, Guinea Pig, Monkey, etc., including half-life, biodistribution, bioavailability and safety evaluation. Our expertise lies in performing surgical techniques on laboratory animals and:

  • Single/Multiple dose pharmacokinetics
  • Surgical skills (jugular, carotid, femoral and bile cannulation and perfusion)
  • Exteriorization of various organs like ovary, testis, etc.
  • Various routes of administration (PO, IV, IP, SC, IM, Topical, IT, Ocular, Infusion, etc.)
  • Toxicokinetics
  • Tissue distribution studies
  • In vivo blood brain barrier studies
  • PK/PD relationship studies
  • Pharmacokinetic analysis of non-clinical studies (WinNonlin)

We develop LC-MS/MS based bio-analytical methods to identify and quantify test articles and metabolites in blood, urine and other biological fluids/tissues.


At GVK BIO we have the experience, the competency and the technological prowess to solve complex analytical problems relating to method development, validation and sample analysis. We provide fast and efficient method development for quantitative measurement of compounds in biological fluids, by chromatographic and mass spectrometric techniques.