In Vivo Pharmacology Studies | In Vivo Models | In Vivo Services

In Vivo pharmacology is the study of the biological effects of a drug in living organisms. In Vivo models or animal models of human diseases are used to observe the physiological effects of NCE or large molecules. Testing drug candidates in animals is necessary step to understand the candidate behavior in the whole organism, starting from bioavailability and going through efficacy in diseased models and to a potential toxicity of either the compound itself or its metabolite(s).

GVK BIO has assembled a highly experienced team of scientists with strong background in drug discovery and in-depth knowledge in various disease models across therapeutic areas. Our scientific team has extensive experience helping patrons with the selection of appropriate animal models of disease, as well as collaborating to design new animal disease models to meet the specific needs of a patron or drug discovery programs. Our team of In Vivo services scientists are well aligned with expectations from the industry regarding quality of scientific data and timeline deliverables.

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We offer In Vivo pharmacology services in accordance with customer’s-designed protocols supporting their discovery needs on flexible basis: from delivering standalone studies to taking over responsibility for planning and executing studies. GVK BIO offers early research and proof-of-concept pharmacology studies in relevant animal models to assist efficacy evaluations. We can customize our In Vivo pharmacology models to meet clients’ unique objectives.

Our animal vivarium is accredited by AAALAC and OLAW for ethical treatment of animals. All the animal experiments at GVK BIO are conducted in accordance with IAEC approved protocols. All experimental procedures involving animals are carried out to the highest standards of animal welfare in state-of-the-art facilities. GVK BIO’s rodent facility is also certified by OHSAS for strictly following all recommended rules for health and safety of our employees.

We utilize a plethora of acute, mechanistic, pharmacodynamic models relevant to the target biology to assess target engagement, efficacy and PK/ PD co-relation. Our efficacy models are validated with appropriate standard of care and supported by rigorous statistical analysis.

Why Partner with GVK BIO for In Vivo Studies

  • 1

    Partnering Approach
    Your research partner needs to understand your vision. That is why you place a strong emphasis on working closely with your contract R&D company to develop appropriate or ‘fit-for-purpose’ study designs to meet your key objectives. With emphasis on communication, GVK BIO can work with you in lock step on your path to drug discovery.
  • 2

    Holistic Approach
    Optimize the relationship between In Vivo pharmacology and toxicity. We bring together scientific experts from both disciplines on to your project, to advance the best compounds. This provides you with the best chances of long-term success throughout your drug development journey.
  • 3

    Quickness in Delivery
    Our team takes a systematic approach to advance your NCEs or large molecules in appropriate animal models. Most importantly, we help ensure your compound works in a relevant and accepted disease model.
  • 4

    Quality Animals
    Different rodent species used for In Vivo pharmacology studies and toxicity studies are procured from internationally reputed vendors such as Taconic and Charles River who have established breeding facilities locally in Hyderabad.
  • 5

    Wide Customer Base
    We have the experience in working on vast range of requirements from our client base that includes large, mid-size pharma and virtual companies across globe. We are sensitive to the requirements of each of these segments.

Specialty of Animal House

  • Our team of In Vivo Pharmacology scientist  believe in high quality, reproducible, decision-enabling data with continuous scientific engagement, provided in a timely and cost-effective manner
  • AAALAC approved vivarium facility
  • Animal maintenance and experiments are as per the OSHAS and IAEC guidelines
  • Highest quality animals procured locally from internationally reputed vendors such as Taconic and Charles River
  • Physical examination and clinical symptoms of animals by trained veterinarian during the entire tenure of the study
  • Strong IP protection practices
  • Environmental Health & Safety is an essential part of our values system
  • Offer comprehensive list of more than 50 validated animal models in the therapeutic areas of oncology, cardiovascular, metabolic disease, fibrosis, inflammation and pain
  • Bioanalytical and biomarker support for measuring PK-PD correlations
  • FTE or FFS service models to provide best value to client

Infrastructure & Expertise

  • AAALAC accredited and OHSAS certified animal facility
  • 2 Veterinarians, 14 scientists including PhDs with collective 50 years of disease biology experience
  • Each therapeutic area is headed by an experienced PhD disease biologist
  • Scientists with broad drug discovery experience from target identification/validation to IND submission
  • Extensive in-house experience of validating rodent models and providing screening support for clients
  • Compounds screened and characterized by our team have progressed to IND studies
  • Efficacy models are supported by appropriate PD biomarker & histopathology analysis
  • Dedicated veterinarians and pathologists to support efficacy and toxicity studies

Our In Vivo Pharmacology capabilities include

  • Testing numerous medicinal entities, including small molecules and antibodies
  • Inducing disease by multiple techniques – chemical, surgical and diet
  • Dosing by commonly used administration routes – p.o, i.v, s.c & i.p
  • Performing necropsies, histopathology, IHC, gene expression and clinical chemistry
  • Executing standard or custom tailored protocols

In Vivo Pharmacology Models for CVMD

GVK BIO’s In Vivo pharmacology team has a strong expertise in supporting drug discovery in the area of cardiovascular and metabolic diseases.

GVK BIO offers a range of developed and well characterised target engagement/efficacy models of Type 1 and Type 2 diabetes, obesity, renal diseases, with a particular focus on NASH (hepatic fibrosis). In addition, our team routinely develop models to fit our collaborator’s specific project needs.

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In Vivo Pharmacology Models for Pain & Inflammation

GVK BIO’s scientists have in-depth knowledge and expertise in a wide range of rodent models in pain and inflammation. Wide range of inflammatory and pain (acute & chronic) have been developed and validated. The studies are conducted in a blinded fashion to avoid any bias.

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In Vivo Pharmacology Models for Oncology

GVK BIO has a long-standing expertise in oncology, including contributing to multiple clinical candidates. GVK BIO offers a range of xenograft & syngeneic  coupled with broad range of bio-marker read-outs.

In Vivo Pharmacology Models for Fibrosis

GVK BIO scientists have developed acute & chronic fibrosis models of Liver, Kidney and Lungs. The models have been validated known reference compounds and are supported by bio-marker, clinical chemistry and histopathology analysis.

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