Liver Fibrosis | NASH Models | CCl4 Model | STZ + HFD NASH

 

GVK BIO offers custom Liver Fibrosis models like AMLN NASH, STZ + HFD NASH and CCl4 induced liver fibrosis to meet our clients’ specific requirements. In terms of extensive experience, our liver fibrosis team will set up a detailed research plan based on your specific needs be it diet or chemical induced fibrosis and provide solutions to evaluate the efficiency of potential therapeutic agents for liver fibrosis.

Liver Fibrosis Models

STZ + HFD NASH Model : It is a translational model for human diseases like fatty liver, NASH and HCC created by combination of chemical, streptozotocin (STZ) (Post natal day-2) and high fat diet (HFD, 60% kcal) (from 4 weeks till end of the treatment)​.

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Amylin Liver NASH Model (AMLN NASH) Is a diet induced Liver Fibrosis model for human NASH diseases created by feeding  high fat diet (AMLN diet, 40 kcal% (mostly palm oil), 20 kcal% fructose and 2% cholesterol; D09100310) in male C57BL/6 mice.

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CCl4 Liver Fibrosis Model (Rat & Mouse) : This fibrosis animal model shares several characteristics with human fibrosis of different etiologies​, chronic CCl4 intoxication is a well-known model for producing oxidative stress and chemical hepatic injury in the liver.

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