In Vitro ADME Services

GVK BIO provides comprehensive tailor-made ADME services for drug discovery organizations. Our unique expertise in in vitro ADME services lies in innovative innovative approach incorporating advanced technologies in elucidating drugability properties of compound. Expert study designs, in vitro assays and data interpretation from the in vitro ADME services team at GVK BIO allow you to characterize your drug candidate’s ADME properties and its potential for drug interactions. Many of our in vitro assays have multiple formats available to suit the different stages of the drug discovery pipeline, allowing us to offer a flexible approach to our ADME services.

In vitro ADME assays are an important part of a successful drug development program aiding in the critical decision making process by offering metabolic information about drug-drug interactions, pharmacokinetics, absorption and potential toxicities. The in vitro ADME services team provides validated workflows to bridge chemistry, biology and pharmacology for your projects. This enables us to provide high quality data that our customers’ can truly rely on, in their decision making. We are pledged to work closely with our customers in providing  in vitro ADME services with quick turnaround time and way forward.

Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK studies and bioanalysis

TIER 1 ASSAYS

  • Solubility (Kinetic and Thermodynamic)
  • Log P, Log PKa & Log D
  • PAMPA (GIT, BBB and Skin)
  • Metabolic stability in microsomes (2 time points,Multispecies)
  • Plasma protein binding (Single concentration)
  • Cocktail CYP inhibition, HLM (single concentration, 5/8 CYPs)
  • Cassette IV PK
  • Cassette PO PK

TIER 2 ASSAYS

  • Plasma protein binding (3 concentrations, 3-5 species)
  • Metabolic stability in microsomes and hepatocytes (Intrinsic Clearance)
  • Plasma/blood stability
  • CYP inhibition (IC50, Ki)
  • Met ID (soſt spot), species comparison
  • Blood / plasma Partitioning
  • Time dependent inhibition / Mechanism based inactivation
  • Reactive metabolite screening
  • MDCK & Caco-2 permeability
  • Rodent Bioavailability studies
  • Mouse IV PO PK
  • Dog Bioavailability Studies
  • Blood brain barrier Penetration studies (Brain and CSF) in rodents

TIER 3 ASSAYS

  • Reaction Phenotyping
    • Multi day PK study in Rodents
    • Ascending dose K studies in Rodents
    • Ascending dose PK studies in dogs
    • CYP Induction
  • Tissue distribution studies
  • MTD studies in rat and mouse
  • Mechanistic PK studies (Biliary excretion, First pass metabolism,BAL study)
  • Metabolite identification and characterization from in-vitro and in-vivo samples

IND PACKAGE

  • Bioanalytical method development and validation in rodent and non-rodents
  • Single-and multiple-dose pharmacokinetics
  • Dose proportionality and absolute bioavailability in rodents and non-rodents
  • Plasma protein binding in rodents and non-rodents
  • In vitro CYP450 inhibition (1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4/5) in human liver microsomes
  • CYP induction in human hepatocytes
  • In vitro metabolism in rat, mouse, dog and human hepatic preparations
  • Reaction Phenotyping in recombinant CYPs or UGTs or other enzyme systems
  • Non-CYP enzymes mediated metabolism study
  • P-gp and BCRP transporter studies using Caco2 cell line

Our in vitro ADME services team has extensive experience in assay development and validation. We also specialize in the custom in vitro ADME assay development. We have validated critical early stage screening assays against literature data. As a result of the sophisticated lab instruments and streamlined process, we can provide for your in vitro ADME/Tox needs in a cost-efficient and timely manner.

Get a quote for in vitro ADME services by specifying your details right away ! Our in vitro ADME services team will contact you at the earliest.

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