Rodent PK Studies and Services

GVK BIO performs exploratory rodent pharmacokinetics studies (rodent PK Studies) for understanding the fate of the drug in vivo. In Rodent PK services, rats and mice are the rodent species routinely used because of their susceptibility to toxic challenge, tumor induction and carcinogenicity.

In addition, we have a vast amount of background information available on their survival, physiology, pathology and susceptibility to different test items. With over 15 years of specialized experience, our rodent PK Services are designed to provide fast-turnaround and low cost studies with clear and frequent client communications.

We are highly trained to perform rodent surgeries and to dose animals under various routes. We have ready-to-use animal protocols for a variety of disease models and we can perform PK/PD studies in multiple species, including mouse and rat.

The combined experience and training of our team of rodent PK Studies veterinarians specialized in research animal diseases and our scientists in the fields of cellular and molecular biology and toxicology provides our clients with a complete understanding of their research projects. Starting with our practice Director, who can provide expert guidance and recommendations on formulations, administration routes and dosing regimens, you can identify your specific choices for the rodent PK Studies.

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The need to understand the distribution and clearance of the drug in the animals is very important in the process of drug development. GVK BIO can perform the in-life phase of the study and collect blood and tissue for analysis.

Our rodent PK Services can support drug discovery through:

  • Pharmacokinetics, bioavailability studies in rodent species
  • tissue distribution, protein-binding and excretion balance studies
  • Toxicokinetics in toxicity studies and safety pharmacology
  • In vitro and in vivo metabolism studies, with profiling and metabolite identification
  • Biopharmaceutical assessment (pre-formulation and formulation studies)

We are dedicated to provide quality rodent PK services to assist pharmaceutical and biotechnology companies in preclinical development and candidate selection. GVK offers the clients a broad spectrum of high quality services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, with cost-efficiency and fast turnaround. The test articles range from small molecules to large molecules, such as protein and antibody.

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