Psoriasis is a chronic autoimmune skin disease in which the life cycle of the skin cells is accelerated which lead to solid build-up of cells on the surface of the skin. The extra skin cells form scales and red patches that are itchy and painful.
Researchers are trying to find out ways to reduce the life cycle of the skin cells and potential drugs are being tested in preclinical psoriasis models in rodents
The cause of psoriasis is fully not determined understood, it is basically thought to be related to an over active immune system.
T cells normally present in body usually defend against foreign substances, such as viruses, bacteria and other foreign bodies.
In the case of psoriasis, the T cells attack healthy skin cells by mistake and increase production of skin cells.
A lot of potential drugs are tested in IMQ-induced preclinical psoriasis model in mice.
Potential causes of Psoriasis
- Infections – Such as Respiratory, throat, staph and skin infections
- Cuts and Bruises – bug bite, damage caused due to accidents or due to extreme radiation
- Extreme weather conditions
- Excess release of stress hormones
- Smoking and alcohol consumption
- Skin Tattoos
- Vitamin D deficiency
- Medications — ACE inhibitors, lithium laced medication, beta blockers, antimalarial drugs, iodides Plaquenil, hydroxychloroquine and NSAIDs
- Certain type of food rich in natural inflammatory arachidonic acid