Peptide
Chemistry
Synthesis

Peptide Chemistry Synthesis

A dedicated peptide chemistry team is specialized in the synthesis of linear, cyclic, staple and modified peptides using a solution, solid or hybrid technology platforms. Our excellent infrastructure and facilities allow to synthesize diverse peptides in short time with high purities.

Capabilities

  • Linear peptides greater than 100mers
  • Support to supply mg to Kg scale
  • Reactions at ambient and elevated temperature

Infrastructure

  • Automated peptide synthesizer
  • 48-Mini block and work stations
  • Large jacketed reactors for scale-up of peptides
  • Centrifuge, lyophilizer and prep purification instruments

N-Terminal and Side-Chain Modifications:

  • PEGylation
  • Acetylation, acylation (e.g. lipopeptides)
  • Biotinylation
  • Phosphorylation (phosphoserine, tyrosine and threonine), sulfation and glycosylation reaction
  • Introduction of maleimido groups, chelating moieties, chromophores and fluorophores, etc

C-Terminal Modifications:

  • Amidation (peptide amide)
  • Peptide alcohols and aldehydes
  • C-Terminal esters and thioesters

Cyclizations:

  • Single or multiple disulfide bridges
  • Head-to-tail cyclisation
  • Side chain cyclisation (e.g. lactam bridge, thioether)
  • Hydrocarbon-stapled peptides

Conjugates:

  • Conjugation with linker, biomolecules, carbohydrates, heterocycles, steroids, etc., with spacer, amino acids and others
  • Modification of peptide bond (site specific phosphorylation from azide) in the final molecule

Nucleoside & Nucleotide Chemistry

Team has extensive knowledge in synthesizing nucleosides, nucleotides and phosphoramidate molecules with modifications in the sugar and base motifs. Their expertise even extends in synthesis of modified amino sugar, halogenated sugars, S & N containing monosaccharides, chiral lactones, neuraminic acid and glycosidation with non-carbohydrate moieties.

In addition, nucleoside based complex building blocks have been synthesized and used for focused library generation. All compounds are characterized and corroborated with extensive analytical studies like 1H, 19F, 31P-NMR, LCMS and HPLC analysis.

Material Science

High quality light sensitive electronic grade material preparation (OLED precursors)

Scientists at GVK BIO are trained to carry out preparation of high grade electronic materials for their application in Organic Light Emitting Diodes (OLED), Printed Electronics (PE), Nanomaterials and Biomaterials. These scientists have excellent skills and expertise in handling light and air sensitive compounds on a unique platform.

Brochure

Peptide Chemistry

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Brochure

Extractables and Leachables Solutions

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Whitepaper

Flow Chemistry vs. Batch Processes

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