Peptide
Chemistry
Synthesis

Peptide Chemistry Synthesis

A dedicated peptide chemistry team is specialized in the synthesis of linear, cyclic, staple and modified peptides using a solution, solid or hybrid technology platforms. Our excellent infrastructure and facilities allow to synthesize diverse peptides in short time with high purities.

Capabilities

  • Linear peptides greater than 100mers
  • Support to supply mg to Kg scale
  • Reactions at ambient and elevated temperature

Infrastructure

  • Automated peptide synthesizer
  • 48-Mini block and work stations
  • Large jacketed reactors for scale-up of peptides
  • Centrifuge, lyophilizer and prep purification instruments

N-Terminal and Side-Chain Modifications:

  • PEGylation
  • Acetylation, acylation (e.g. lipopeptides)
  • Biotinylation
  • Phosphorylation (phosphoserine, tyrosine and threonine), sulfation and glycosylation reaction
  • Introduction of maleimido groups, chelating moieties, chromophores and fluorophores, etc

C-Terminal Modifications:

  • Amidation (peptide amide)
  • Peptide alcohols and aldehydes
  • C-Terminal esters and thioesters

Cyclizations:

  • Single or multiple disulfide bridges
  • Head-to-tail cyclisation
  • Side chain cyclisation (e.g. lactam bridge, thioether)
  • Hydrocarbon-stapled peptides

Conjugates:

  • Conjugation with linker, biomolecules, carbohydrates, heterocycles, steroids, etc., with spacer, amino acids and others
  • Modification of peptide bond (site specific phosphorylation from azide) in the final molecule

Brochure

Peptide Chemistry

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Brochure

Extractables and Leachables Solutions

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Whitepaper

Flow Chemistry vs. Batch Processes

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