Specialty
Chemistry

Specialty Chemistry
At GVK BIO, the sophisticated infrastructure has been put in place to carry out

Infrastructure

  • Automated Peptide Synthesizer
  • Automated block reactors, mini blocks with work stations, specialized reactions vessels
  • Centrifuge, Lyophilizer, purification instruments

Capabilities

  • Linear peptides upto 60mers
  • mg to Kg scalability

N-terminal and Side-Chain Modifications

  • PEGylation
  • Acetylation, acylation (e.g. lipopeptides)
  • Biotinylation
  • Phosphorylation (phosphoserine, tyrosine and threonine), sulfation and glycosylation
  • Introduction of maleimido groups, chelating moieties, chromophores and fluorophores, etc

C-Terminal Modifications

  • Amidation (peptide amide)
  • Peptide alcohols and aldehydes
  • C-terminal esters and thioesters

Cyclizations

  • Single or multiple disulfide bridges
  • Head-to-tail cyclization
  • Side chain cyclization (e.g. lactam bridge, thioether)
  • Hydrocarbon-stapled peptides

Conjugates

  • Conjugation with linker, biomolecules, carbohydrates, heterocycles, steroids, etc., with spacer, amino acids and others
  • Modification of peptide bond (site specific phosphorylation from azide) in the final molecule

Nucleoside & nucleotide chemistry

Team has extensive knowledge in synthesizing nucleoside, nucleotides and phosphoramidate etc., with manipulation in sugar and base motifs. Their expertise even extends in synthesis of modified amino sugar, halogenated sugars, S & N containing monosaccharides, chiral lactones, neuraminic acid and glycosidation with non-carbohydrate moieties.

Brochure

Discovery Chemistry Solutions

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Whitepaper

Flow Chemistry vs. Batch Processes

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