Whitepapers

In vivo Pre-Clinical Platforms to Study Post-COVID Lung Damage and Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease where scar formation in the lungs leads to decreased function. There is a high demand to develop and evaluate novel therapeutics for IPF

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In Vivo Models & In Vitro Assays for Human RSV Infection - Pre-Clinical Antibody, Small Molecule & Vaccine Development

Respiratory syncytial virus (RSV) infection is the major cause of severe respiratory illness in infants and young children, as well as in immune compromised individuals and the elderly. RSV infection of the lungs and respiratory tract leads to a range

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A Novel Cell-based Screening Assay for Cholesterol Biosynthetic Pathway Inhibition Using the RapidFire HTMS Platform

CYP51A1 is a heme-thiolate monoxygenase which participates in an obligatory step in the cholesterol biosynthetic pathway and catalyzes the formation of critical intermediates in humans. This enzyme is also a critical component of the ergosterol biosynt

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Flow Chemistry vs. Batch Processes

Chemical development is a time-consuming, expensive and labour-intensive process. This results in a high environmental load and a long time-to-market for a drug molecule. As this could affect the viability and accessibility of the pharmaceutical produc

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Developability Assessment of Small Molecules

Developability assessment or preformulation studies of small molecule is an important part of drug discovery process leading to selection of New Chemical Entities (NCEs) for clinical studies. These studies include physicochemical and biopharmaceutical

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A Highly Reproducible In Vivo Model for Bleomycin-Induced Lung Fibrosis in Mice to Evaluate Drugs for the Treatment of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a type of chronic lung disease characterized by a progressive and irreversible decline in lung function. It is a progressive and ultimately fatal disease that causes scarring and thickening of the lung tissue lead

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Pharmacokinetic Strategies in CNS Drug Discovery

Our understanding of the design and functioning of the Central Nervous System has dramatically improved over the last two decades. In spite of this, the discovery and clinical development of drugs for many CNS disorders has remained elusive. The failur

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